César de la Fuente is on a mission to combat antimicrobial resistance by looking at nature's own solutions. César de la Fuente is an associate professor at the University of Pennsylvania, where he leads the Machine Biology Group. When he was just a teenager trying to decide what to do with his life, César de la Fuente compiled a list of the world's biggest problems. He ranked them inversely by how much money governments were spending to solve them. Antimicrobial resistance topped the list. Twenty years on, the problem has not gone away.

This paper presents Decorate3D, a versatile and user-friendly method for the creation and editing of 3D objects using images.

We study the optimal design of additive mechanisms for vector-valued queries under $ε$-differential privacy (DP). Given only the sensitivity of a query and a norm-monotone cost function measuring utility loss, we ask which noise distribution minimizes expected cost among all additive $ε$-DP mechanisms. Using convex rearrangement theory, we show that this infinite-dimensional optimization problem admits a reduction to a one-dimensional compact and convex family of radially symmetric distributions whose extreme points are the staircase distributions. As a consequence, we prove that for any dimension, any norm, and any norm-monotone cost function, there exists an $ε$-DP staircase mechanism that is optimal among all additive mechanisms. This result resolves a conjecture of Geng, Kairouz, Oh, and Viswanath, and provides a geometric explanation for the emergence of staircase mechanisms as extremal solutions in differential privacy.

Color image generation has a wide range of applications, but the existing generation models ignore the correlation among color channels, which may lead to chromatic aberration problems. In addition, the data distribution problem of color images has not been systematically elaborated and explained, so that there is still the lack of the theory about measuring different color images datasets. In this paper, we define a new quaternion Wasserstein distance and develop its dual theory. To deal with the quaternion linear programming problem, we derive the strong duality form with helps of quaternion convex set separation theorem and quaternion Farkas lemma. With using quaternion Wasserstein distance, we propose a novel Wasserstein quaternion generative adversarial network. Experiments demonstrate that this novel model surpasses both the (quaternion) generative adversarial networks and the Wasserstein generative adversarial network in terms of generation efficiency and image quality.

Numerous graph neural network (GNN)-based algorithms have been proposed to solve graph-based combinatorial optimization problems (COPs), but methods to explain their predictions remain largely undeveloped. We introduce ARM-Explainer, a post-hoc, model-level explainer based on association rule mining, and demonstrate it on the predictions of the hybrid geometric scattering (HGS) GNN for the maximum clique problem (MCP), a canonical NP-hard graph-based COP. The eight most explanatory association rules discovered by ARM-Explainer achieve high median lift and confidence values of 2.42 and 0.49, respectively, on test instances from the TWITTER and BHOSLIB-DIMACS benchmark datasets. ARM-Explainer identifies the most important node features, together with their value ranges, that influence the GNN's predictions on these datasets. Furthermore, augmenting the GNN with informative node features substantially improves its performance on the MCP, increasing the median largest-found clique size by 22% (from 29.5 to 36) on large graphs from the BHOSLIB-DIMACS dataset.

Holography offers significant potential for AR/VR applications, yet its adoption is limited by the high demands of data compression. Existing deep learning approaches generally lack rate adaptivity within a single network. We present RAVQ-HoloNet, a rate-adaptive vector quantization framework that achieves high-fidelity reconstructions at low and ultra-low bit rates, outperforming current state-of-the-art methods. In low bit, our method exceeds by -33.91% in BD-Rate and achieves a BD-PSNR of 1.02 dB from the best existing method demonstrated by the rate-distortion curve.